All football in England below the three divisions that make up the National League will end immediately and all results will be expunged.
It means there will be no promotion or relegation in these leagues.
The same will happen in the women's game below the Women's Super League and Championship level.
However, the National League, National League North and South, WSL and Women's Championship will continue towards a conclusion "as quickly as possible".
The Football Association said it was "reviewing all options" to complete the men's FA Cup, which had reached the quarter-final stage, and other cup competitions.
The coronavirus pandemic has decimated all sports, with fixtures suspended earlier this month. "These are challenging circumstances for English football and all decisions taken are in the best interests of the game," said an FA statement.
"Our primary concern will always be for the safety and welfare of clubs, players, staff, officials, volunteers and supporters during this unprecedented time.
"Today's steps take into account the financial impact during this uncertain period, whilst considering the fairest method on how the sporting outcomes for the season will be decided, with the integrity of the leagues in mind."
The decision applies to steps three to seven in men's non-league football which contains 91 leagues.
All "grassroots" divisions below these tiers have also finished, but it has still yet to be decided whether these seasons are to be voided.
A planned restructure of the non-league system at lower levels has now been delayed until 2021-22.
In women's football, tiers three to seven have also ended.